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Turkish Journal of Cancer
1994, Volume 24, Number 3, Page(s) 138-146
[ Summary ]
Treatment of metastatic adenocarcinoma of prostate with orchiectomy and flutamide
EŞMEN BALTALI, GÖRGÜN AKPEK, GÜLTEN TEKUZMAN, İBRAHİM BARIŞTA, AYŞE KARS, DİNÇER FIRAT
Hacettepe University Institute of Oncology, Ankara-Turkey

This prospective trial was undertaken to determine the benefits of the combination of bilateral orchiectomy with flutamide in terms of objective response rate, response duration, overall survival and side effects. Between 1989 and 1993, twenty-five consecutive patients with previously untreated metastatic carcinoma of the prostate were treated with flutamide 250 mg tid and orchiectomy. Response was classified according to objective criteria of the National Prostate Cancer Project (NPCP). Tumor grade was studied to determine its relationship to treatment response. Complete, partial and stable responses were obtained in 12%, 60%, 4% of patients respectively. An overall response rate of (CR+PR) 72%, was achieved. Patients with grade II and grade Ill prostate cancer were the most responsive group to flutamide therapy. Six patients (24%) progressed to a more advanced stage. Median overall (CR+PR) response duration is 14 months (3-43+). Median overall survival has not been reached and 56% of all patients are still alive at the time of evaluation. The toxicity and side effects of flutamide therapy have been tolerable and no additional drug or discontinuation of treatment was needed. Frequent side effects were hot flushes, decrease in libido, muscle cramps, edema formation and diarrhea. We concluded that the combination of flutamide and orchiectomy is of significant value in the treatment of patients with advanced stage prostate carcinoma from the aspect of both response to therapy and quality of life.

[ Summary ]
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