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Turkish Journal of Cancer
2000, Volume 30, Number 1, Page(s) 15-23
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Cyclin-D1 protooncogen expression in prostate cancer
EMİN ÖZBEK1, BÜLENT MIZRAK2, MUSTAFA ÖZBEK3, SÜLEYMAN BÜYÜKBERBER4, MÜRSEL DAVARCI1
Departments of 1Urology,2Pathology and 4Internal Medicine, İnönü University School of Medicine, Malatya-Turkey
3Department of Internal Medicine, Dışkapı Social Security Hospital, Ankara-Turkey

Cyclin D1, a cell cycle regulator essential for G1 phase progression, has been implicated in the pathogenesis of certain cancers. High levels of these proteins have been reported in certain human malignancies and have been implicated in aberrant cell division and dysregulated tumor growth. In this study, 30 prostate cancer and 25 benign prostate tissues were studied for cyclin D1 expression using an immunohistochemical technique. All of the primary prostate cancer samples revealed regions of moderate to strongly positive nuclear staining for cyclin D1, however there was no nuclear staining in the benign prostate tissue except weak staining in the stroma. There was a positive correlation between Gleason grade and staining intensity for cyclin D1. The increased expression of cyclin D1 in prostate cancer samples suggests that further studies on the expression of this gene and related genes may be of interest in understanding the pathogenesis of prostate cancer. The positive correlation between Gleason grade and protein expression may be used as a prognostic marker in prostate cancer. Further studies are needed to confirm this suggestion.

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