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Turkish Journal of Cancer
2009, Volume 39, Number 1, Page(s) 018-025
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Performance of total prostate specific antigen and free prostate specific antigen ratio for screening prostate cancer in a Turkish population
BURCU BARUTÇUOĞLU1, A. ERKİN BOZDEMİR1, YEŞİM ERTAN2, CEYDA KABAROĞLU1, SADIK TAMSEL3, MİNE HEKİMGİL2, ÇAĞ ÇAL4, DİLEK ÖZMEN1, OYA BAYINDIR1
1Ege University School of Medicine, Departments of Clinical Biochemistry, İzmir-Turkey
2Ege University School of Medicine, Departments of Pathology, İzmir-Turkey
3Ege University School of Medicine, Departments of Radiology, İzmir-Turkey
4Ege University School of Medicine, Departments of Urology, İzmir-Turkey

The aim of the study was to report the diagnostic performance of total prostate-specific antigen (tPSA) and free prostate-specific antigen ratio (%fPSA). The diagnostic performances of tPSA and %fPSA were evaluated in 364 men by ROC curves, sensitivity, specificity and diagnostic odds ratio calculations. One hundred and sixty-two patients were diagnosed as prostate cancer (PCa) and 202 as normal. The median tPSA levels and %fPSA ratios differed significantly, 11.16 ng/mL and 11 versus 6.51 ng/mL and 20 in PCa and normal groups, respectively. At tPSA levels between 4-10 ng/mL; area under curve (AUC)%fPSA was greater than AUCtPSA. 16 as a cut off value of %fPSA was the optimum choice revealing a sensitivity of 0.703, a specificity of 0.656 and diagnostic odds ratio of 4.254(95% CI 2.157- 8.39 ). %fPSA ratio is an expedient screening marker in PCa. In our laboratory, at tPSA levels between 4- 10 ng/mL, %fPSA ratio of 16 offers a preferable diagnostic performance. [Turk J Cancer 2009;39(1):18-25]

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