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Turkish Journal of Cancer
2009, Volume 39, Number 4, Page(s) 160-162
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Intraneural perineurioma of the median nerve
VOLKAN GÜRKAN1, GAFFUR KARACA1, GÖKHAN BÜLENT SEVER1, BİLGE BİLGİÇ2
1Dr. Lütfi Kırdar Kartal Training and Research Hospital, 1st Orthopedics Clinic, İstanbul-Turkey
2İstanbul University İstanbul Medical Faculty, Department of Pathology, İstanbul-Turkey

Perineuriomas present as focal intraneural peripheral nerve or isolated soft tissue lesions. In this case report, we focus on the intraneural variant of perineurioma. Intraneurial perineurioma which generally presents as a slowly progressive painless focal motor neuropathy characterized slowly histologically by onion–bulb shaped whorls, was first described by Imaginario et al.[] in 1964. The etiology of these lesions has been controversial with some authors asserting that this lesion is a reactive process associated with trauma and other proposing that the lesion is a true neoplasm[-]. Thus the lesion has been labeled with different names including ‘localized hypertrophic mononeuropathy' and ‘perineuroma'[,-]. The evidence relating these lesions to trauma has been scarce, and both intraneurial and extraneurial variants are now believed to represent clonal neoplasms associated with abnormalities of chromosome 22[,]. However, in recent literature the lesion continues to be referred to interchangeably as perineurioma and localized hypertrophic mononeuropathy[,].

We present a case of a median nerve perineurioma which has caused carpal tunnel syndrome and treated by surgical procedures. [Turk J Cancer 2009;39(4):158-160]


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