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Turkish Journal of Cancer
1992, Volume 22, Number 1, Page(s) 25-38
[ Summary ]
Langerhans cell histiocytosis: a report of 99 cases
CEYDA KARADENİZ, MÜNEVVER BÜYÜKPAMUKÇU, FAİK SARIALİOĞLU, SAFİYE GÖĞÜŞ, CANAN AKYÜZ, TEZER KUTLUK

Ninety-nine patients (64 male, 35 female) with a diagnosis of langerhans cell histiocytosis (LCH) were managed at the Pediatric Oncology Department of Hacettepe Children’s Hospital from 1972 through 1988. The patients were categorized into group IA-localised disease (33 patients), group IB-multifocal disease without organ dysfunction (37 patients) and group II patients with organ dysfunction (29 patients). The median ages in each group were as follows: 5 years in group IA, 3 years in group IB, 1.5 years in group II. Group IA patients were treated mainly by surgery and chemotherapy with or without irradiation, in group lB patients primary chemotherapy with or without irradiation and surgery, and in group II patients chemotherapy was given alone. The two year survival rates were 100% in group IA, 81% in group lB and 47% in group II. The survival in the second year below the age of two was 62%, while it was 91% over two years of age. However as the age of the patients decreased, the groups of the patients changed from group IA to group lB and to II and organ dysfunction at diagnosis emerged as the major adverse prognostic factor in children with LCH.

[ Summary ]
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