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Turkish Journal of Cancer
1992, Volume 22, Number 3, Page(s) 98-102
[ Summary ]
Marked heterogeneity of ferritin and some other tumor markers in effusions due to malignancy
SEMRA PAYDAŞ , ÖZOĞUL SARGIN

Ferritin, CEA, AFP and HCG levels were measured in serum and fluid samples taken from patients with malignant disease and compared with fluid associated with tuberculosis and various transudates. Serum ferritin levels were between 6-430, 37-745, 45-500 and fluid ferritin levels were between 24-1000, 0.8-760, 8.5-870 ng/ml in patients with malignancy, tuberculosis and transudate respectively. The ratio between fluid ferritin and serum ferritin was calculated as 5.97 ± 6.68, 3.10 ± 3.97 and 1.99 ± 149, 3.10 ± 3.97 and 1.99 ± 1.49 in these study groups respectively and statistically non-significant. CEA, HCG and AFP levels were highly variable in these samples. Our results suggested that ferritin levels in serum and effusions are highly variable in malignant and nonmalignant groups. Ratio between fluid and serum ferritin more than 5 can be useful for approach to malignant effusion but less then 5 can not rule out the maliginant effusion. High levels of CEA, HCG and AFP in effusions may be suggestive of malignant effusion but low levels do not rule out malignant effusion.

[ Summary ]
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