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Turkish Journal of Cancer
1996, Volume 26, Number 4, Page(s) 139-145
[ Summary ]
Relationship between flow cytometric DNA ploidy with pathologic grade and stage in 28 bladder carcinomas
ABDÜLKADİR REİS1, YAVUZ ÖZORAN1, ABDULLAH SİVRİKAYA2, AYDIN AYDIN2, YAVUZ TEKELİOĞLU3, GÖKHAN HAROVA1
Departments of 1Pathology, 2Urology and 3Histology and Embryology, Karadeniz Technical University Medical School, Trabzon-Turkey

DNA distribution of 28 biopsy specimens from patients with transitional cell carcinoma of the bladder was evaluated by flow cytometry. All tumors were graded according to the modified Bergkvist and staging was done according to the Jewett systems. One of the 5 grade I tumors, 1 of the 4 grade IIa tumors, 2 of the 4 grade IIb tumors, 8 of the 10 grade Ill tumors and all of the 5 grade IV tumors were aneuploid. Noninfiltrating tumors displayed diploid (100%), whereas infiltrating tumors generally showed aneuploid peak. The relation between the grade and the stage of the tumors and the DNA ploidy was statistically significant. This study showed that a good correlation exists between the histopathological grade and stage with the DNA ploidy in transitional cell carcinomas of bladder.

[ Summary ]
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