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Turkish Journal of Cancer
2004, Volume 34, Number 3, Page(s) 101-105
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Role of nm23 expression in nephroblastoma in determining prognosis and metastatic potential
SAFİYE AKTAŞ1, GÜLDEN DİNİZ1, RAGIP ORTAÇ1, CANAN VERGİN2
1Dr. Behçet Uz Children’s Hospital, Departments of Pathology , İzmir-Turkey
2Dr. Behçet Uz Children’s Hospital, Departments of Pediatric Hematology, İzmir-Turkey

Nm23 gene family is associated with metastasis suppression and differentiation with known 4 types. Nm23 genes are expressed in different tumors where the levels are associated with reduced or increased metastatic potential. The aim of this study is to search for prognostic role and metastatic importance of nm23 protein expression in nephroblastomas. Monoclonal antibody specific for nm23 was applied immunohistochemically by LSAB method in formalin fixed paraffin embedded tissue sections of nephroblastoma in 30 children between 1-10 years of age in different stages of disease. Its prognostic role and relation with metastasis and other factors were searched. Seventeen of the cases were female (56.7%) while 13 were male (43.3%). The mean age was 4.3±2.4 (1-10). Thirteen cases were stage I (43.3%), one case was stage II (3.3%), 10 cases were stage III (33.3%), while 6 were stage IV (20%). Twenty-one cases were alive, while 9 cases were exitus. Mean survival time was 87.2±49.7 (8-154) months. Nm23 was positive in 20 cases (66.7%) and negative in 10 cases (33.3%). The mean survival time for nm23 negative cases was 50.90 months, while it was 105.35 months for positive cases. In Spearman correlation analysis, stage was positively related with nm23 status (p=0.0001) and Cox Regression analysis indicated nm23 protein expression as an independent factor for metastasis (p=0.010) and for prognosis (p=0.001). Log Rank Survival analysis showed a significant difference between nm23 positive and negative cases (p=0.019). Prognosis was better in nm23 positive cases. Our results revealed that negative nm23 protein expression might be a predictor for metastasis in nephroblastomas and it is an independent prognostic factor. It would worth studying the prognostic importance of nm23 in nephroblastoma and other tumors. [Turk J Cancer 2004;34(3):101-105]

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