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Turkish Journal of Cancer
2004, Volume 34, Number 3, Page(s) 106-109
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P53 and Ki-67 expression in nasopharyngeal carcinomas
ESİN ÖZEL1, GÜLAY ÖZBİLİM1, M. GAMZE DALMAZ2, KENAN GÜNEY3
1Akdeniz University, Departments of Pathology, Antalya-Turkey
2Akdeniz University, Departments of Radiation Oncology Antalya-Turkey
3Akdeniz University, Departments of Ear, Nose &Throat, Antalya-Turkey

This study was performed to investigate any relation between the histological subtypes of nasopharyngeal carcinomas (NPCs) and the expression of p53 and Ki-67 in NPCs. Fifteen cases which were diagnosed between 2000 and 2003 in Akdeniz University Faculty of Medicine, Department of Pathology and treated with radiotherapy were included in this study. The specimens were stained immunohistochemically with p53 and Ki-67. Twenty-six percent of the cases were undifferentiated carcinoma, 60% were non-keratinizing type and 14% were keratinizing type squamous cell carcinoma (SCC). Ki-67 labeling index was as follows; 11% in undifferentiated carcinomas, 27% in non-keratinizing type and 32% in keratinizing SCC. We found +3 p53 intensity in 25% of undifferentiated carcinomas, 37% of the nonkeratinizing SCC and in both of the keratinizing SCC. Although limited number of cases were included in this study, we found correlation between histopathologic subtypes, p53 and Ki-67 expression in NPCs. [Turk J Cancer 2004;34(3):106-109]

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