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Turkish Journal of Cancer
2005, Volume 35, Number 2, Page(s) 081-087
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Serum tumor markers in small cell lung carcinoma patients treated with cyclophosphamide, epirubicin and vincristine combination
HASAN ŞENOL COŞKUN1, ÖZLEM ER2, MUSTAFA ALTINBAŞ2, METİN ÖZKAN2, SERDAR SOYUER2
1Süleyman Demirel University Medical Faculty, Department of Medical Oncology, Isparta
2Erciyes University Medical Faculty, MK Dedeman Oncology Hospital, Department of Medical Oncology, Kayseri-Turkey

Tumor markers are frequently used in the management of cancer patients especially for determination of the extent of the disease at diagnosis and monitorization of response to therapy. Neuron specific enolase (NSE), carcinoembryogenic antigen (CEA), lactic dehydrogenase (LDH) and ferritin were analyzed in 84 patients with small cell lung cancer who were treated with cyclophosphamide, epirubicin, and vincristine (CEV) combination. Sixty-six patients were male and 18 were female. Median age was 58 years (34-74). NSE was significantly higher in extensive disease than limited disease. There was no significant difference in other markers between stages. Although there was no statistically significant difference in CEA, ferritin, LDH before and after treatment, NSE levels decreased significantly in all patients and limited stage disease after treatment. In extensive stage, changing of NSE levels before and after treatment was not significant. We obtained higher response rate in patients with normal NSE levels. Progression free and overall survival was higher in patients with normal NSE levels (p=0.05 and p=0.09 respectively). NSE is in concordance with stage and may reflect response to therapy and early survival in patients who were treated with cyclophosphamide, epirubicin and vincristine.[Turk J Cancer 2005;35(2):81-87].

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