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Turkish Journal of Cancer
2005, Volume 35, Number 4, Page(s) 171-176
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CYP1A1, GSTM1 and NQO1 gene polymorphisms: Genetic risk factors for small cell lung cancer
AYŞE DEMİRKAN1, BURÇAK VURAL1, ZEKİ ÜSTÜNER2, KAZIM UYGUN3, BETÜL ÖZTÜRK AÇIKALIN4, DUYGU DERİN4, PINAR SAİP4, UĞUR ÖZBEK1
1Istanbul University, Experimental Medical Research Institute, Department of Genetics, İstanbul
2Eskişehir University Medical School, Department of Medical Oncology, Eskişehir
3Trakya University Medical School, Department of Medical Oncology, Edirne
4Istanbul University, Oncology Institute, İstanbul-Turkey

Smoking plays the major role in the development of lung cancer. CYP1A1, GSTM1 and NQO1 gene polymorphisms are thought to be related with some types of cancer considering their important roles in the detoxification pathway of certain carcinogens present in tobacco smoke. These polymorphisms are being widely studied in tobacco related cancer; especially in lung cancer. In this study, we investigated the frequencies of these metabolic gene polymorphisms in our smoking small cell lung cancer patient group (n=93) and ever smoking healthy control subjects (n=126). CYP1A1 ile/val, GSTM1 null/present and NQO1 pro/ser genotype analysis were performed using standard techniques. Compared with the healthy controls, NQO1 ser/ser genotype and ser allele frequency were significantly higher in SCLC patients’ group [p=0.045 and p=0.013 (OR = 1.82; 95% CI 1.13 - 2.93), respectively]. We have found that CYP1A1 ile/ile + NQO1 pro/pro combined genotype was significantly higher in the control group [p<0.001 (OR = 3.45; 95% CI 1.79 - 6.65)]. Also, CYP1A1 ile/ile+GSTM1 non-null+NQO1 pro/pro combined genotype was significantly higher in the control group than the SCLC patients [p<0.001 (OR = 3.51; 95% CI 1.82 - 6.75)]. [Turk J Cancer 2005;35(4):171-176].

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