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Turkish Journal of Cancer
2006, Volume 36, Number 1, Page(s) 005-010
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The relationship between the risk of lung cancer and the exon 5 (ILE105VAL) polymorphism of glutathione S-transferase P1 (GSTP1) gene
FATMA SÖYLEMEZ1, ETEM AKBAŞ1, ERTUĞRUL SEYREK2, HİCRAN MUTLUHAN1, HANDAN ÇAMDEVİREN3
1Mersin University, Faculty of Medicine, Medical Biology and Genetics, Departments of Mersin-Turkey
2Mersin University, Faculty of Medicine, Oncology and Departments of Mersin-Turkey
3Mersin University, Faculty of Medicine, Biological Statistics, Departments of Mersin-Turkey

Lung cancer is one of the cancers which are seen all around the world and whose mortality rate is high. Many environmental factors and genotypes of individuals play an important role in the process of lung cancer. Previous epidemiologic studies have suggested that cancer risks are modified by some genetic polymorphisms. Glutathione S-transferase P1 (GSTP1) gene polymorphism is the most explored in all of these polymorphisms. GSTP1, the most abundant GST isoform in the lung, metabolizes numerous carcinogenic compounds including polycyclic aromatic hydrocarbons (PAH), a tobacco carcinogen. Utilizing a hospital-based case-control study, we investigated the association between GSTP1 polymorphisms at exon 5 with lung cancer risk in the Turkish population living in Mersin. The study population consisted of 50 lung cancer cases that were diagnosed at the Clinical Oncology Department of the Mersin University Hospital and 50 healthy controls matched for sex and age. Genomic DNA from patients and healthy controls was extracted from peripheral blood leukocytes and PCR-RFLP assay were used to genotype the GSTP1 polymorphisms. A statistically significant difference was observed only in the frequencies of the GSTP1 exon 5 allele and genotype between the control group and the case group (p=0.037). There was an association between the exon 5 mutant genotype (GG) and overall lung cancer risk (OR 7.55, 95% CI 1.127-50.596). [Turk J Cancer 2006;36(1):5-10].

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