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Turkish Journal of Cancer
2006, Volume 36, Number 1, Page(s) 019-022
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Serum AOPP, selenium and vitamin E levels after irradiation
YILDIZ GÜNEY1, ÜMMİHANİ ÖZEL TÜRKÇÜ2, ÖZNUR MERTOĞLU2, AYŞE BİLGİHAN2, AYŞE HİÇSÖNMEZ1, MELTEM NALÇA ANDRİEU1, CENGİZ KURTMAN1
1Ankara University School of Medicine, Department of Radiation Oncology, Ankara-Turkey
2Gazi University School of Medicine, Department of Biochemistry, Ankara-Turkey

Proteins are susceptible to free radical damage. We measured advanced oxidation protein products (AOPP), selenium and vitamin E levels in serum after whole body irradiation in doses of 8 Gy and 15 Gy in guinea pigs. After 24 hours from irradiation, the serum AOPP levels were increased significantly at 15 Gy dose with respect to the control levels (p<0.05). In both of the irradiated groups, Vitamin E and selenium levels did not change (p>0.05) in serum with respect to the control group, after 24 hours from irradiation. We found that gamma-irradiation caused dose dependent effect on AOPP levels. This result may be related to the fact that a high dose of ionizing irradiation cause excessive oxidative stress while antioxidants such as vitamin E and selenium were not affected after 24 hours from irradiation. [Turk J Cancer 2006;36(1):19-22].

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