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Turkish Journal of Cancer
2006, Volume 36, Number 1, Page(s) 027-030
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Can flow-cytometry be used at diagnosis and follow-up in neuroblastoma with bone marrow involvement?
YAVUZ KÖKSAL1, İSMAİL REİSLİ1, FİGEN DOĞU2, CANAN UÇAR1, HASAN ACAR3, ÜMRAN ÇALIŞKAN1
1Selçuk University, Meram Medical Faculty, Department of Pediatrics, Konya-Turkey
2Ankara University, Faculty of Medicine, Department of Pediatric Immunology, Ankara-Turkey
3Selçuk University, Meram Medical Faculty, Department of Genetics, Konya-Turkey

A 4.5-year-old boy was admitted to our clinic with fever, which had persisted for one month, weakness, and hand, arm and knee pain. Physical examination was remarkable for pallor, the movement of the right knee was painful and restricted, yet both knees were same in diameter. The peripheral blood smear revealed moderate immature lymphocytosis. Bone marrow aspiration revealed uniform cells with narrow cytoplasm and hyperchromatic nuclei which formed a “rosette” scene. On bone marrow flow-cytometry examination, CD45(–)/CD44(+)/CD56(+) cells were 70% positive. The urinary VMA level was 41.6 mg/24 h. There was an anterior paramediastinal mass and vertebral destructions in thoracal computed tomography (CT). Cranial CT and magnetic resonance imaging (MRI) revealed duramater involvement and numerous subdural tumors. A paravertebral mass that extended into the spinal canal was determined with spinal MRI. Stage IV neuroblastoma (NB) was diagnosed and ENSG-3C chemotherapy protocols including cisplatin, etoposide, ifosfamide, mesna, vincristine and adriamycine was given. After two cycle of the chemotherapy, bone marrow aspiration was normal and CD45(-)/CD44(+)/CD56(+) cells were 5% positive. Following treatment, he has been in remission for 18 months. Flow-cytometry may be useful for the diagnosis and follow-up of NB with bone marrow involvement. [Turk J Cancer 2006;36(1):27-30].

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