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Turkish Journal of Cancer
2007, Volume 37, Number 4, Page(s) 154-157
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Fanconi anemia with the presentation of abdominal rhabdomyosarcoma followed by acute myeloid leukemia
SEVGİ GÖZDAŞOĞLU1, GÜLSAN YAVUZ2, HALUK GÖKÇORA3, ZÜMRÜT UYSAL1, EMEL BABACAN1, IŞIK BÖKESOY4, ÖZDEN TULUNAY5, AYHAN ÇAVDAR1
1Ankara University School of Medicine, Departments of Pediatric Hematology, Ankara-Turkey
2Ankara University School of Medicine, Departments of Pediatric Oncology, Ankara-Turkey
3Ankara University School of Medicine, Departments of Pediatric Surgery, Ankara-Turkey
4Ankara University School of Medicine, Departments of Genetics, Ankara-Turkey
5Ankara University School of Medicine, Departments of Pathology, Ankara-Turkey

The objective of this study is to present an unusual case of Fanconi anemia (FA) with an initial presentation of abdominal rhabdomyosarcoma followed by acute myeloid leukemia (AML). Although epithelial cancers are more often seen in FA patients, rarities such as osteosarcomas, soft-tissue tumors and brain cancers have been reported in the literature. The present case was treated with VACA treatment (vincristine, actinomycin D, cyclophosphamide and adriamycin) and radiotherapy following initial assessment through surgery and histopathological evaluation. A second malignancy AML developed 17 months after completion of initial treatment and the patient died at 2 months remission and 6 months survival following the diagnosis of AML. [Turk J Cancer 2007;37(4):154-157]

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