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Turkish Journal of Cancer
2000, Volume 30, Number 4, Page(s) 148-154
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CLINICAL USEFULNESS OF SERUM ASSAYS OF CARCINOEMBRYONIC ANTIGEN AND BETA 2-MICROGLOBULIN IN THE DIAGNOSIS AND DISCRIMINATION OF METASTASIS OF LUNG CANCER
FARUK TAŞ, ADNAN AYDINER, VİLDAN YASASEVER, RİAN DİŞÇİ, ERKAN TOPUZ
Department of Medical Oncology, Istanbul University Institute of Oncology, Istanbul-Turkey

The aims of this current study were to evaluate the diagnostic properties and discriminative values in the metastatic disease of serum carcinoembryonic antigen (CEA) and beta 2-microglobulin (BMG) in lung cancer. One hundred and thirty-five patients with lung cancer were evaluated. Sixty-six (48.8%) patients had squamous cell, 31 (22.9%) had adenocarcinoma, 28 (20.7%) had small cell, 5 (3.7%) had large cell, and 5 (3.7%) had mixed (adenosquamous) histology. Mean age was 60 (range 33-75) and 122 (90.4%) patients were male. Fifteen (53.6%) patients with small cell lung cancer (SCLC) had extensive and 37 (34.5%) patients with non-small cell lung cancer (NSCLC) had metastatic (stage IV) disease. Serum CEA and BMG values were obtained at baseline. Upper limits of normal levels for CEA and BMG were 10 ng/ml and 3 mg/L, respectively. Chi-square test was used for comparisons. Positive rates of BMG were higher than CEA in almost all histologic types, but these were not significant. While BMG values did not reveal any difference based on stage, CEA was elevated in NSCLC (p<0.05). In subset, squamous cell lung cancer had only prominent CEA rise in metastatic than nonmetastatic disease (p<0.01).

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