[ Main Page | Editorial Board | About | Instructions ]
[ Table of Contents | Archive | Archive Search | Online Submission | E-mail ]

Turkish Journal of Cancer
2003, Volume 33, Number 1, Page(s) 51-54
[ Summary ] [ Full Text ] [ PDF ]
Androgen-related hepatocellular tumor of the liver associated with Fanconi’s anemia
SAFİYE AKTAŞ1, HURŞİT APA2, GÜLDEN DİNİZ1, AYŞE ERBAY3, RAGIP ORTAÇ1, CANAN VERGİN2, İRFAN KARACA4, NEVRA ELMAS5, YILDIRAY YÜZER6
Dr. Behçet Uz Children's State Hospital, Departmens of 1Pathology, 2Pediatrics, 3Pediatric Oncology and 4Pediatric Surgery,
Ege University Faculty of Medicine, Departmens of 5Radiology and 6Surgery, İzmir, Turkey

Hepatocellular tumors are quite rare in pediatric age group. Its association with Fanconi’s anemia and androgen therapy is well known but the pathogenesis is controversial. Occurrence of significant dysplasia causes great problems to differentiate it as hepatocellular adenoma or hepatocellular carcinoma. In this paper a 13 years old male case of hepatocellular tumor associated with Fanconi’s anemia and androgen therapy is presented. He was given androgen and steroid therapy for 5 years and he had had hepatitis C virus infection for 3 years before the multifocal hepatic tumors were observed. Androgen therapy was witheld and surgery was performed twice. Patients taking androgenic-anabolic steroids should be carefully monitored with US and CT and tumor markers should be measured. The worrisome pathology that may occur in hepatic tumor in children particularly with androgen therapy does not necessarily predict malignant behaviour.

[ Summary ] [ Full Text ] [ PDF ]
[ Main Page | Editorial Board | About | Instructions ]
[ Table of Contents | Archive | Archive Search | Online Submission | E-mail ]