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Turkish Journal of Cancer
1995, Volume 25, Number 4, Page(s) 149-154
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Accumulation of p53 protein in astrocytomas: immunohistochemical study using D07 MAb
GÜLFİLİZ GÖNLÜŞEN1, SUZAN ZORLUDEMİR1, EDİZ COŞAR1, FAZİLET KAYA SELÇUK1, REFİK BURGUT2, İLHAN TUNCER1
Departments of 1Pathology and 2Biostatistics, Çukurova University Medical School, Adana-Turkey
Keywords: p53 protein, astrocytoma
Summary
Accumulation of p53 protein was examined in tissue sections of 40 astrocytomas and compared with the histological grade of tumor, age and sex of the patients. lmmunohistochemical staining with monoclonal antibody (D07) was positive in 15.4% of grade II and 45% of grade lll-IV astrocytoma cases; whereas none of the pilocytic astrocytomas (grade I) were positive for p53. lmmunoreactivity showed a strong correlation with tumor grade. There was no significant difference between age and sex of p53 positive and negative cases.
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